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Multicentre study o...
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Bergkvist, LUppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
(författare)
Multicentre study of detection and false-negative rates in sentinel nodebiopsy for breast cancer
- Artikel/kapitelEngelska2001
Förlag, utgivningsår, omfång ...
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2002-11-29
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Oxford University Press (OUP),2001
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-62275
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-62275URI
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https://doi.org/10.1046/j.0007-1323.2001.01948.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1958352URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Sentinel node biopsy has recently evolved as a means of staging the axilla in breast cancer with minimal surgical trauma. The aim of this prospective multicentre study was to identify factors that influenced the detection and false-negative rates during the learning phase.METHODS: Data on all 498 sentinel node biopsies performed between August 1997 and December 1999 in Sweden were collected.RESULTS: A sentinel node was found in 450 patients (90 per cent). Preoperative scintigraphy visualized 83 per cent of all sentinel nodes. The detection rate was higher with same-day injection of tracer than with injection the day before (96 versus 86 per cent; P < 0.01). Dye injected less than 5 min or more than 30 min before the start of the operation lowered the detection rate (less than 60 per cent versus more than 65 per cent; P = 0.02). The detection rate varied from 61 to 100 per cent between surgeons. The false-negative rate was 11 per cent. The presence of multiple tumour foci and a high S-phase fraction increased the risk of a false-negative sentinel node, whereas the number of operations performed by each surgeon was less important.CONCLUSION: Training of the individual surgeon influenced the detection rate, as did timing of tracer and dye injection. The false-negative rate seemed to be related to biological factors.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Frisell, JKarolinska Institutet,Uppsala universitet
(författare)
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Liljegren, GUppsala universitet
(författare)
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Celebioglu, FKarolinska Institutet,Uppsala universitet
(författare)
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Damm, SUppsala universitet
(författare)
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Thörn, MKarolinska Institutet,Uppsala universitet,Institutionen för kirurgiska vetenskaper
(författare)
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Uppsala universitetInstitutionen för kirurgiska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Surgery: Oxford University Press (OUP)88:12, s. 1644-16480007-13231365-2168
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