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Donor and recipient...
Donor and recipient endothelial cell population of the transplanted human cornea: a two-dimensional imaging study.
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- Lagali, Neil (författare)
- Linköpings universitet,Östergötlands Läns Landsting,Ögonkliniken US/LiM,Oftalmiatrik,Hälsouniversitetet
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- Stenevi, Ulf, 1943 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Sahlgrens University Hospital
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- Claesson, Margareta, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Sahlgrens University Hospital
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- Fagerholm, Per (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM
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- Hanson, Charles, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Weijdegård, Birgitta (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Strömbeck, Anne-Sophie (författare)
- Uppsala universitet,Oftalmiatrik,University Uppsala Hospital
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(creator_code:org_t)
- Association for Research in Vision and Ophthalmology (ARVO), 2010
- 2010
- Engelska.
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Ingår i: Investigative ophthalmology & visual science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783 .- 0146-0404. ; 51:4, s. 1898-904
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose. To elucidate the pattern of donor and recipient endothelial cell populations in transplanted human corneas and determine the degree to which donor endothelial cells survive in the graft. Methods. Thirty-six corneal grafts were collected from recipients of opposite sex to the donor, at the time of retransplantation for various indications. Cells from the endothelial side of the grafts were harvested, preserving their relative location on the endothelium. Fluorescence in situ hybridization of the sex chromosomes enabled each cell to be identified as donor- or recipient-derived. Images of the graft endothelium were assembled, to depict the pattern of cell population of the graft, and the proportion of donor cells present was estimated. Results. Endothelial cells of donor origin were found in 26 of 36 grafts (72.2%)-in one case, up to 26 years after transplantation. The proportion of donor endothelium ranged from 2% to 99%; however, there was no significant correlation of this proportion with postoperative time (P = 0.19). The mean annual rate of donor cell loss correlated negatively with the time to graft failure by endothelial decompensation (P = 0.002). Endothelial images indicated a highly variable pattern of recipient cell repopulation of the graft. A tendency toward donor cell retention in transparent, successful grafts was noted; however, this feature alone was not a reliable indicator of long-term graft transparency. Conclusions. Two-dimensional imaging of the corneal graft endothelium revealed a variable pattern and extent of donor and recipient cell population, indicating the highly dynamic nature of the corneal endothelium after transplantation.
Nyckelord
- Adult
- Aged
- Aged
- 80 and over
- Cell Count
- Cell Survival
- physiology
- Chromosomes
- Human
- X
- metabolism
- Chromosomes
- Human
- Y
- metabolism
- Corneal Transplantation
- Endothelium
- Corneal
- cytology
- metabolism
- Female
- Humans
- In Situ Hybridization
- Fluorescence
- Male
- Microscopy
- Fluorescence
- Middle Aged
- Prospective Studies
- Reoperation
- Tissue Donors
- Transplantation
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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