WFRF:(Lundqvist Anna)
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- Orlova, AnnaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS (author)
Cellular processing of (125)I- and (111)in-labeled epidermal growth factor(EGF) bound to cultured A431 tumor cells
- Article/chapterEnglish2000
Publisher, publication year, extent ...
- 2000
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-63148
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-63148URI
- https://doi.org/10.1016/S0969-8051(00)00148-7DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Low molecular weight of epidermal growth factor (EGF) enables better intratumoral penetration in comparison with larger targeting proteins, but the cellular retention of EGF-associated radioactivity is poor for directly iodinated EGF. An attempt was made to improve intracellular retention by the use of metal-diethylenetriaminepentaacetic acid or nonphenolic linker (N-succinimidyl-para-iodobenzoate) as labeling agents. The use of nonphenolic linker did not improve retention of the radioactivity in A431 carcinoma cell line. The use of the radiometal label provided an appreciable prolongation of radioactivity residence inside the cell.
Subject headings and genre
- 125I-para-iodo-benzoate
- 111In-DTPA
- EGF
- A431 cells
- Intracellular retention
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Bruskin, AlexanderUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS (author)
- Sjöström, AnnaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS(Swepub:uu)annsjost (author)
- Lundqvist, HansUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS (author)
- Gedda, LarsUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS(Swepub:uu)larsgedd (author)
- Tolmachev, VladimirUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS(Swepub:uu)vladtolm (author)
- Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)
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- In:Nuclear Medicine and Biology27:8, s. 827-350969-80511872-9614
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