Sökning: id:"swepub:oai:DiVA.org:uu-63722" >
Hormone replacement...
-
Riman, TomasUppsala universitet,Institutionen för kvinnors och barns hälsa
(författare)
Hormone replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
-
Oxford University Press (OUP),2002
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-63722
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-63722URI
-
https://doi.org/10.1093/jnci/94.7.497DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:1953676URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
BACKGROUND: Estrogen replacement therapy (ERT), which is mainly used to relieve climacteric symptoms, increases a woman's risk for uterine endometrial cancer and epithelial ovarian cancer (EOC). Estrogens are often combined with progestins in hormone replacement therapy (HRT) to reduce the risk of uterine endometrial cancer. Data on the association between HRT including progestins and EOC risk are limited. This nationwide case-control study examined EOC risk in relation to HRT regimens with sequentially added progestins (HRTsp) and continuously added progestins (HRTcp). METHODS: Between 1993 and 1995, we enrolled 655 histologically verified incident case patients with EOC and 3899 randomly selected population controls, all 50-74 years of age. Data on HRT use were collected through mailed questionnaires. Multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by the use of unconditional logistic regression. RESULTS: Risks of EOC were elevated among ever users as compared with never users of both ERT (OR = 1.43, 95% CI = 1.02 to 2.00) and HRTsp (OR = 1.54, 95% CI = 1.15 to 2.05); risks were elevated for serous, mucinous, and endometrioid subtypes. For all EOC types combined, the greatest risk increases were seen with hormone use exceeding 10 years. Ever use of HRTcp was not associated with increased EOC risk relative to HRTcp never use (OR = 1.02, 95% CI = 0.73 to 1.43). The risk of EOC was elevated among HRTsp ever users as compared with HRTcp ever users (OR = 1.78, 95% CI = 1.05 to 3.01). ORs for EOC after ever use of low-potency estrogens were 1.18 (95% CI = 0.89 to 1.55) for oral and 1.33 (95% CI = 1.03 to 1.72) for vaginal applications, but no relationship was seen between EOC risk and duration of use. CONCLUSION: Ever users of ERT and HRTsp but not HRTcp may be at increased risk of EOC.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Dickman, Paul W.Karolinska Institutet
(författare)
-
Nilsson, StaffanUppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
(författare)
-
Correia, Nestor
(författare)
-
Nordlinder, Hans
(författare)
-
Magnusson, Cecilia M.Karolinska Institutet
(författare)
-
Weiderpass, ElisabeteKarolinska Institutet
(författare)
-
Persson, Ingemar R.
(författare)
-
Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of the National Cancer Institute: Oxford University Press (OUP)94:7, s. 497-5040027-88741460-2105
Internetlänk
Hitta via bibliotek
Till lärosätets databas