Sökning: WFRF:(Öhman P)
> (2000-2004) >
A single nucleotide...
A single nucleotide polymorphism in the promoter region of the osteoprotegerin gene is related to intima-media thickness of the carotid artery in hypertensive patients : The Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA)
-
- Brändström, Helena (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden
-
- Stiger, Fredrik (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Sweden
-
- Kahan, Thomas (författare)
- Karolinska Institutet
-
visa fler...
-
- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos,Department of Medical Sciences, Uppsala University, Sweden
-
- Nyström, Fredrik (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
-
- Öhman, K. P. (författare)
- Linköpings universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för medicin och vård,Hälsouniversitetet,Departments of Experimental and Clinical Science, Astra Zeneca R&D Mölndal, Sweden
-
- Malmqvist, K. (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Division of Internal Medicine, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
-
- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Medical Sciences, Uppsala University, Sweden
-
- Kindmark, Andreas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University, Sweden and Departments of Experimental and Clinical Science, Astra Zeneca R&D Mölndal, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2009-07-08
- 2004
- Engelska.
-
Ingår i: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 13:3, s. 152-157
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and in previous studies has been shown to regulate osteoclast activity and differentiation. Ablation of the OPG gene in mice results in calcification of the aorta and renal arteries. We have previously reported an association between a single nucleotide polymorphism in the promoter region of OPG and vascular morphology and function in healthy humans. The objective with this study was to confirm our previous results in a larger population, and in addition, to study subjects with hypertension. The OPG genotype was determined by restriction fragment length and the intima-media thickness (IMT) of the common carotid artery was measured by ultrasound in 100 patients with hypertension and left ventricular hypertrophy, and 75 healthy normotensive control subjects. In the hypertensive group subjects with the CC genotype (n=24) showed a significantly increased IMT compared to those with the TC (n=52, p=0.007) and TT (n=24, p=0.009) genotype, in the hypertensive group only (mean +/- SD for TT=0.88 +/- 0.21 mm, TC=0.90 +/- 0.16 mm, CC=1.05 +/- 0.31 mm). The allele distribution did not differ between hypertensive and control individuals. The present study confirms our previous finding and shows that polymorphism in the promoter region of OPG is associated with vascular morphology in hypertensive subjects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adrenergic beta-Antagonists/therapeutic use
- Adult
- Atenolol/therapeutic use
- Carotid Arteries/*pathology
- Female
- Genotype
- Glycoproteins/*genetics
- Humans
- Hypertension/drug therapy/*genetics/*pathology
- Hypertrophy; Left Ventricular/drug therapy/genetics/pathology
- Male
- Middle Aged
- Polymorphism; Single Nucleotide
- Promoter Regions (Genetics)
- Receptors; Cytoplasmic and Nuclear/*genetics
- Research Support; Non-U.S. Gov't
- Sweden
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas