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New sterically stab...
New sterically stabilized vesicles based on nonionic surfactant, cholesterol, and poly(ethylene glycol)-cholesterol conjugates.
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Beugin, S (författare)
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- Edwards, Katarina (författare)
- Uppsala universitet,Fysikalisk-kemiska institutionen
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- Karlsson, Göran (författare)
- Uppsala universitet,Fysikalisk-kemiska institutionen
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visa fler...
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Ollivon, M (författare)
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Lesieur, S (författare)
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visa färre...
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(creator_code:org_t)
- 1998
- 1998
- Engelska.
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Ingår i: Biophysical Journal. - 0006-3495 .- 1542-0086. ; 74:6, s. 3198-3210
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Monomethoxypoly(ethylene glycol) cholesteryl carbonates (M-PEG-Chol) with polymer chain molecular weights of 1000 (M-PEG1000-Chol) and 2000 (M-PEG2000-Chol) have been newly synthesized and characterized. Their aggregation behavior in mixture with diglycerol hexadecyl ether (C(16)G(2)) and cholesterol has been examined by cryotransmission electron microscopy, high-performance gel exclusion chromatography, and quasielastic light scattering. Nonaggregated, stable, unilamellar vesicles were obtained at low polymer levels with optimal shape and size homogeneity at cholesteryl conjugate/ lipids ratios of 10 mol% M-PEG1000-Chol or 5 mol% M-PEG2000-Chol, corresponding to the theoretically predicted brush conformational state of the PEG chains. At 20 mol% M-PEG1000-Chol or 10 mol% M-PEG2000-Chol, the saturation threshold of the C(16)G(2)/cholesterol membrane in polymer is exceeded, and open disk-shaped aggregates are seen in coexistence with closed vesicles. Higher levels up to 30 mol% lead to the complete solubilization of the vesicles into disk-like structures of decreasing size with increasing PEG content. This study underlines the bivalent role of M-PEG-Chol derivatives: while behaving as solubilizing surfactants, they provide an efficient steric barrier, preventing the vesicles from aggregation and fusion over a period of at least 2 weeks.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- TRANSMISSION ELECTRON-MICROSCOPY
- LIPOSOMAL DRUG-DELIVERY
- OCTYL GLUCOSIDE
- PHASE-BEHAVIOR
- SODIUM STIBOGLUCONATE
- PHYSICAL-PROPERTIES
- CIRCULATION TIME
- IN-VIVO
- GLYCOL
- POLYMERS
- Analytical chemistry
- Analytisk kemi
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