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  • Söderbergh, AnnikaUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)

Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I

  • Article/chapterEnglish2004

Publisher, publication year, extent ...

  • The Endocrine Society,2004
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-72225
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72225URI
  • https://doi.org/10.1210/jc.2003-030279DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:19911774URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17 alpha-hydroxylase, glutamic acid decarboxylase 65, aromatic L-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison's disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.

Subject headings and genre

  • Adolescent
  • Adult
  • Autoantibodies/*analysis
  • Autoantigens/immunology
  • Biological Markers
  • Child
  • Child; Preschool
  • Cohort Studies
  • Enzymes/immunology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Polyendocrinopathies; Autoimmune/complications/*immunology
  • Research Support; Non-U.S. Gov't
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Myhre, Anne Grethe (author)
  • Ekwall, OlovUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Gebre-Medhin, GennetUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Hedstrand, HåkanUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Landgren, EvaUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Miettinen, Aaro (author)
  • Eskelin, Petra (author)
  • Halonen, Maria (author)
  • Tuomi, Tiinamaija (author)
  • Gustafsson, JanUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo (author)
  • Husebye, Eystein S. (author)
  • Perheentupa, Jaakko (author)
  • Gylling, Mikhail (author)
  • Manns, Michael P. (author)
  • Rorsman, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Kämpe, OlleUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)(Swepub:uu)ollekamp (author)
  • Nilsson, ThomasUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe) (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society89:2, s. 557-5620021-972X1945-7197

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