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Increased dopamine ...
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Kindlundh, Anna M SUppsala universitet,Institutionen för farmaceutisk biovetenskap
(författare)
Increased dopamine transporter density in the male rat brain following chronic nandrolone decanoate administration
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
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Elsevier BV,2004
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-72693
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72693URI
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https://doi.org/10.1016/j.neulet.2003.11.040DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Adolescent males currently employ anabolic-androgenic steroids (AAS) to become intoxicated, besides the traditional desires of an improved physical appearance and enhanced sports performance. Several studies indicate that AAS affect the brain reward system. Recently chronic administration with nandrolone decanoate to male rats has been shown to increase the dopamine transporter (DAT) density in the striatum visualised in vivo by positron emission tomography. The present study aimed to investigate if the increased DAT density could be confirmed using in vitro autoradiography following a comparable regimen of nandrolone treatment. Specific binding of 50 pM [125I] RTI-55 in the presence of 1 microM citalopram was used to label DAT. Two weeks of nandrolone decanoate administration at the supra-therapeutic doses 1, 5 and 15 mg/kg per day increased DAT density in the caudate putamen at all three doses. In conclusion, this study confirms that chronic nandrolone administration increases dopamine transporter density in the CPU and therefore supports the theory that AAS affects the dopamine system in the male rat brain.
Ämnesord och genrebeteckningar
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Anabolic Agents
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Animals
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Autoradiography
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Brain/drug effects/metabolism
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Comparative Study
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Male
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Membrane Glycoproteins
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Membrane Transport Proteins/*drug effects/metabolism
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Nandrolone/*analogs & derivatives/*pharmacology
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Nerve Tissue Proteins
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Rats
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Rats; Sprague-Dawley
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Research Support; Non-U.S. Gov't
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rahman, SadiaUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)sarah838
(författare)
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Lindblom, JonasUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)jli08577
(författare)
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Nyberg, FredUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)frednybe
(författare)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuroscience Letters: Elsevier BV356:2, s. 131-1340304-39401872-7972
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