Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

• The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

Nyckelord

Animals

Cell Differentiation/drug effects

Cell Movement/drug effects

Cells; Cultured

Coronary Vessels/cytology/drug effects

Endothelial Cells/*cytology/*drug effects

Hindlimb/blood supply/drug effects

Humans

Ischemia/chemically induced/*drug therapy/metabolism/*pathology

Mice

Microcirculation/drug effects

Myocardium/metabolism/pathology

Neovascularization; Physiologic/*drug effects

Phosphotyrosine/metabolism

Platelet-Derived Growth Factor/*pharmacology

Receptors; Platelet-Derived Growth Factor/metabolism

Research Support; Non-U.S. Gov't

Signal Transduction

Stem Cells/cytology/*drug effects

MEDICINE

MEDICIN

Publikations- och innehållstyp

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