Circulating adhesion molecules in allergic and non-allergic asthma

Janson, ChristerUppsala universitet,Institutionen för medicinska vetenskaper,Lungmedicin och allergologi (author)

Circulating forms of adhesion molecules (intercellular-adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin ) are related to the turnover of these molecules on the cell surface. In contrast to the other molecules, the levels of E-selectin probably exclusively reflect the activity of endothelial cells. The aim of this study was to compare levels of circulating adhesion molecules in patients with allergic (AA) and non-allergic asthma (NA) and to relate the levels of soluble adhesion molecules to methacholine responsiveness and lung function. The study comprised 19 patients with AA, 15 patients with NA and 17 healthy subjects. Soluble adhesion molecules, spirometry, methacholine responsiveness and peak flow variability was measured. The group of patients with AA had higher levels of sE-selectin than the reference group (P=0.046). Serum levels of sE-selectin correlated significantly with bronchial responsiveness (r=0.76) and peak flow variability (r=0.75) (P<0.01) in the NA but not in the AA group. All adhesion molecules in AA (P<0.05-<0.001), but only sE-selectin in NA (P<0.05), were correlated to airway conductance. sVCAM-1 was reduced by inhaled steroids (P<0.01). Our results indicate that endothelial cells are activated in asthma and that this activity has a bearing on airflow variability and bronchial responsiveness in NA.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Asthma; Adhesion molecules; Bronchial responsiveness; Allergy
Adult
Asthma/*blood/physiopathology
Bronchial Hyperreactivity/blood
Bronchial Provocation Tests
Bronchoconstrictor Agents/diagnostic use
Cell Adhesion Molecules/*blood
E-Selectin/blood
Female
Forced Expiratory Volume
Humans
Intercellular Adhesion Molecule-1/blood
Male
Methacholine Chloride/diagnostic use
Middle Aged
Research Support; Non-U.S. Gov't
Respiratory Hypersensitivity/blood/physiopathology
Vascular Cell Adhesion Molecule-1/blood
Vital Capacity
Lung diseases
Lungsjukdomar

Ludviksdottir, Dora (author)
Gunnbjörnsdóttir, MariaUppsala universitet,Institutionen för medicinska vetenskaper (author)
Björnsson, Eythor H. (author)
Håkansson, LenaUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)lenadouh (author)
Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)pervenge (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Janson, Christer; Ludviksdottir, D ...; Gunnbjörnsdóttir ...; Björnsson, Eytho ...; Håkansson, Lena; Venge, Per

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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