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Effects of 2-methox...
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Davoodpour, PadidehUppsala universitet,Ludwiginstitutet för cancerforskning
(author)
Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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Elsevier BV,2004
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-73054
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73054URI
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https://doi.org/10.1016/j.nucmedbio.2004.03.015DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The purpose of this study was to investigate the potential use of PET in vivo to record cytotoxic effects of 2-methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol. The anti-proliferative and pro-apoptotic effects of 2-ME on human prostate cancer cell (PC3) aggregates in vitro, were correlated with the uptake of fluoro-deoxy-D-glucose, FMAU and choline labelled with 18F, 11C, or 3H. 2-ME clearly reduced growth of PC3 aggregates and induced apoptosis in a dose-dependent manner. However, the uptake of the putative proliferation markers 11C-FMAU or 3H-choline failed to record the growth inhibitory effects of 2-ME on PC3 cell aggregates. The uptake of 18F-FDG was used as a marker for effects on cellular metabolism and also failed to show any dose-dependent effects in PC3 aggregates. The use of these PET-tracers in vivo is therefore not recommended in order to evaluate the cytotoxic effects of 2-ME on human prostate cancer cells.
Subject headings and genre
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Antineoplastic Agents/administration & dosage
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Apoptosis/*drug effects
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Cell Aggregation/drug effects
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Cell Line; Tumor
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Cell Proliferation/*drug effects
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Comparative Study
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Dose-Response Relationship; Drug
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Estradiol/*administration & dosage/*analogs & derivatives
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Humans
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Male
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Neoplasm Staging/methods
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Positron-Emission Tomography/*methods
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Prostatic Neoplasms/drug therapy/*metabolism/pathology/*radionuclide imaging
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Radioisotopes/*diagnostic use/*pharmacokinetics
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Radiopharmaceuticals/diagnostic use/pharmacokinetics
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Reproducibility of Results
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Research Support; Non-U.S. Gov't
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Sensitivity and Specificity
Added entries (persons, corporate bodies, meetings, titles ...)
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Bergström, Mats
(author)
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Landström, MaréneUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)mareland
(author)
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Uppsala universitetLudwiginstitutet för cancerforskning
(creator_code:org_t)
Related titles
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In:Nuclear Medicine and Biology: Elsevier BV31:7, s. 867-8740969-80511872-9614
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