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An ordinary mixed m...
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Sarabi, MahziarUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
(author)
An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects
- Article/chapterEnglish2001
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-73100
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73100URI
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https://doi.org/10.1046/j.1365-201X.2001.00845.xDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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This study was designed to evaluate the effects of an ordinary mixed meal on endothelium-dependent vasodilation. Ten young healthy volunteers were given a mixed meal (minced meat sauce with rice, 900 kcal, 34% of the energy content was fat). In the fasting state, at 60 and 120 min after the start of the meal, endothelium-dependent vasodilation and endothelium-independent vasodilation were evaluated by local infusion of metacholine (4 microg min (-1)) and sodium nitroprusside (10 microg min (-1)) in the brachial artery. Blood flow in the forearm was measured using venous occlusion plethysmography. Endothelium-dependent vasodilation decreased from 15.4 +/- 3.3 (mean +/- SD) at fasting to 13.7 +/- 3.5 mL min (-1) (100 mL tissue)-1 (P < 0.01) 60 min after feeding, but had returned to the fasting level at 120 min. At 60 min, but not in the fasting state, the serum level of free fatty acids was inversely related to endothelium-dependent vasodilation (r=-0.74, P < 0.05), although no significant net changes in FFA levels were seen. Endothelium-independent vasodilation was not affected by the mixed meal. No similar attenuations in endothelium-dependent vasodilation were seen during control meals. In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function.
Subject headings and genre
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Adult
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Blood Flow Velocity/drug effects
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Chemistry; Clinical
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Choline/pharmacology
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Eating/*physiology
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Endothelium; Vascular/drug effects/physiology
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Fasting/physiology/psychology
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Fatty Acids; Nonesterified/blood
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Female
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Food
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Food Deprivation/physiology
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Forearm/blood supply
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Humans
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Male
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Nitroprusside/pharmacology
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Plethysmography
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Triglycerides/blood
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Vasodilation/drug effects/*physiology
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Fugmann, AndreasUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
(author)
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Karlström, BritaUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics(Swepub:uu)britkarl
(author)
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Berne, ChristianUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)chber255
(author)
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Lithell, HansUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
(author)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)larslind
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Acta Physiologica Scandinavica172:2, s. 107-1130001-67721365-201X
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