Substitution of conserved glycine residue by alanine in natural and synthetic neuropeptide ligands causes partial agonism at the stomoxytachykinin receptor.

Keyword

Aequorin/genetics/metabolism

Alanine

Amino Acid Sequence

Amino Acid Substitution/genetics/physiology

Animals

Apoproteins/genetics/metabolism

Biological Assay

Calcium/metabolism

Cell Line

Conserved Sequence

Cyclic AMP/metabolism

Dose-Response Relationship; Drug

Drosophila melanogaster

Glycine

Grasshoppers

Insect Proteins/genetics/metabolism/pharmacology

Ligands

Luminescent Measurements

Molecular Sequence Data

Muscidae

Neuropeptides/genetics/*metabolism/*pharmacology

Receptors; Tachykinin/*agonists/genetics/*metabolism

Recombinant Proteins/genetics/metabolism

Research Support; Non-U.S. Gov't

Sequence Homology; Amino Acid

Structure-Activity Relationship

Tachykinins/genetics/metabolism/pharmacology

Transgenes

Publication and Content Type

ref (subject category)

art (subject category)