Oxetane modified, conformationally constrained, antisense oligodeoxyribonucleotides function efficiently as gene silencing molecules.

Nyckelord

Cell Division/drug effects

Comparative Study

Ethers; Cyclic/*chemistry

Gene Silencing

Humans

K562 Cells

Nucleic Acid Conformation

Oligodeoxyribonucleotides; Antisense/*chemistry/metabolism/*pharmacology

Proto-Oncogene Proteins c-myb/genetics/metabolism

RNA; Messenger/metabolism

RNA; Small Interfering/*chemistry/metabolism/*pharmacology

Research Support; Non-U.S. Gov't

Research Support; U.S. Gov't; P.H.S.

Thionucleotides/chemistry

Publikations- och innehållstyp

vet (ämneskategori)

art (ämneskategori)