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Folic acid suppleme...
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Wentzel, ParriUppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
(författare)
Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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American Diabetes Association,2005
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-73547
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73547URI
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https://doi.org/10.2337/diabetes.54.2.546DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Maternal administration of folic acid diminishes the risk of neural tube defects (NTDs) in offspring, but whether folic acid exerts a similar effect in diabetic pregnancy is unknown. The aim was to investigate whether maldevelopment in rat embryos caused by exposure to diabetes in vivo or high-glucose concentrations in vitro is affected by subcutaneous administration of folic acid to the pregnant mother or by adding the compound to the culture medium, respectively. Exposure of embryos to maternal diabetes in vivo or 30 mmol/l glucose in vitro yielded an increased malformation rate (71 and 88% NTD, respectively) and lowered somite number and crown-rump length compared with control embryos. When we injected folic acid into the diabetic pregnant rat, or added 2 mmol/l folic acid to the culture medium with high glucose, the embryonic parameters improved (3 and 5% NTD, respectively). The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy.
Ämnesord och genrebeteckningar
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Abnormalities/*etiology/prevention & control
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Animals
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Diabetes Mellitus; Experimental/*pathology
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Dietary Supplements
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Female
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Folic Acid/*therapeutic use
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Glucose/*toxicity
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Neural Tube Defects/etiology/prevention & control
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Pregnancy
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Pregnancy in Diabetics/*physiopathology
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RNA/genetics/isolation & purification
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Rats
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Research Support; Non-U.S. Gov't
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Tail/abnormalities/embryology
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gäreskog, MattiasUppsala universitet,Institutionen för medicinsk cellbiologi,Teratology(Swepub:uu)magar103
(författare)
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Eriksson, Ulf JUppsala universitet,Institutionen för medicinsk cellbiologi,Teratology
(författare)
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Uppsala universitetInstitutionen för medicinsk cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association54:2, s. 546-5530012-17971939-327X
Internetlänk
Hitta via bibliotek
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Diabetes
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