SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Molin M.)
 

Sökning: WFRF:(Molin M.) > (2000-2009) > Disturbed morphogen...

  • Molin, Daniël G M (författare)

Disturbed morphogenesis of cardiac outflow tract and increased rate of aortic arch anomalies in the offspring of diabetic rats

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • 2004
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-73554
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73554URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Maternal diabetes (MD) is a risk factor for offspring to develop cardiovascular anomalies; this is of growing clinical concern since the number of women in childbearing age with compromised glucose homeostasis is increasing. Hyperglycemia abrogates cardiovascular development in vitro; however, a link to cardiovascular defects in diabetic offspring remains to be investigated. METHODS: We have studied cardiovascular development in offspring of MD rats by examining serial histological sections of GD 12.0-18.0 offspring. Development of pharyngeal arch artery malformations was analyzed and related to intracardiac anomalies. RESULTS: Pharyngeal arch artery and intracardiac defects were present in 27 of 37 MD GD 13.0-18.0 offspring. Early sixth arch arteries showed abrogated arteriogenesis, whereas fourth arch artery defects developed as a result of abnormal remodeling. Morphometrical analysis showed increased apoptosis in regressing artery segments and reduced apoptosis in persisting artery segments. Double outlet right ventricle with infundibular stenosis (tetralogy of Fallot) was predominantly found in combination with sixth artery defects and pulmonary atresia. As confirmed by morphometric analysis and three-dimensional (3D)-reconstructions, outflow tract defects coincided with endocardial cushion hypoplasia. Cases with teratology of Fallot additionally showed a shorter outflow tract. No relation with apoptosis or disturbed neural crest cell migration was found. CONCLUSIONS: Our data uniquely demonstrate mechanistic differences involved in the development of sixth and fourth artery anomalies. Whereas increased apoptosis induces fourth artery anomalies, pulmonary outflow obstruction abrogates sixth artery differentiation independent of apoptosis. The model presented allows analysis of diabetic conditions on cardiovascular development in vivo, essential for elucidating this teratology.

Ämnesord och genrebeteckningar

  • Animals
  • Aorta; Thoracic/*abnormalities/*embryology
  • Apoptosis
  • Coronary Circulation
  • Diabetes Complications/*embryology/veterinary
  • Disease Models; Animal
  • Female
  • Fetal Development
  • Humans
  • Hyperglycemia/*complications/veterinary
  • Male
  • Pregnancy
  • Pregnancy Complications
  • Rats
  • Rats; Sprague-Dawley
  • Regional Blood Flow
  • Research Support; U.S. Gov't; P.H.S.
  • Risk Factors
  • Tetralogy of Fallot/*etiology

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Roest, Pauline A M (författare)
  • Nordstrand, HannaUppsala universitet,Institutionen för medicinsk cellbiologi (författare)
  • Wisse, Lambertus J (författare)
  • Poelmann, Robert E (författare)
  • Eriksson, Ulf JUppsala universitet,Institutionen för medicinsk cellbiologi (författare)
  • Gittenberger-De Groot, Adriana C (författare)
  • Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Birth Defects Research. Part A. Clinical and Molecular Teratology70:12, s. 927-9381542-0752

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy