Sökning: id:"swepub:oai:DiVA.org:uu-75447" >
Effects of acutely ...
-
Axelsson, JohnKarolinska Institutet
(författare)
Effects of acutely displaced sleep on testosterone.
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
-
The Endocrine Society,2005
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-75447
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-75447URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:1957269URI
-
https://doi.org/10.1210/jc.2005-0520DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
CONTEXT: It is not yet clear whether the diurnal variation in testosterone is regulated by circadian or homeostatic (sleep) influences. OBJECTIVE: The present study tested whether testosterone is driven by a circadian-independent sleep effect by shifting sleep acutely to daytime in a 24-h sampling regiment. DESIGN, SETTING, AND PARTICIPANTS: In the sleep laboratory, seven healthy young men (age, 22-32 yr) participated in three conditions: habituation (sleep between 2300-0700 h), night sleep (2300-0700 h), and day sleep (0700-1500 h), the latter two in a balanced order. INTERVENTION AND MAIN OUTCOME MEASURE: Serum testosterone was, in all conditions, sampled by hourly blood drawing for 24 h during constant bed rest. RESULTS: Mean testosterone levels increased as a log-linear function of time (hours) across both sleep periods (b = 4.88; P < 0.001), from 15.3 +/- 2.1 to 25.3 +/- 2.2 nmol/liter during night sleep and from 17.3 +/- 2.1 to 26.4 +/- 2.9 nmol/liter during day sleep. Similarly, mean testosterone levels decreased with time (log-linear) awake (b = -1.80; P < 0.001). There was also evidence of a weak circadian component (acrophase ranging between 0651-0924 h) and an increase with time in the laboratory. Moreover, all these effects, except for the increase during sleep, differed significantly between individuals. CONCLUSION: In conclusion, testosterone increased during sleep and fell during waking, whereas circadian effects seemed marginal. Individual differences were pronounced.
Ämnesord och genrebeteckningar
-
Adult
-
Circadian Rhythm/*physiology
-
Humans
-
Male
-
Regression Analysis
-
Research Support; Non-U.S. Gov't
-
Sleep/*physiology
-
Testosterone/*blood
-
Wakefulness/*physiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Ingre, Michael
(författare)
-
Åkerstedt, TorbjörnKarolinska Institutet
(författare)
-
Holmbäck, UlfUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Institutionen för medicinska vetenskaper(Swepub:uu)ulfholmb
(författare)
-
Karolinska InstitutetInstitutionen för folkhälso- och vårdvetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:J Clin Endocrinol Metab: The Endocrine Society90:8, s. 4530-50021-972X1945-7197
Internetlänk
Hitta via bibliotek
Till lärosätets databas