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The stem cell facto...
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Lennartsson, JohanUppsala universitet,Ludwiginstitutet för cancerforskning
(författare)
The stem cell factor receptor/c-Kit as a drug target in cancer
- Artikel/kapitelEngelska2006
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LIBRIS-ID:oai:DiVA.org:uu-76065
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-76065URI
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https://lup.lub.lu.se/record/153522URI
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Språk:engelska
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Sammanfattning på:engelska
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Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation and survival cues in tumor cells often occur as a consequence of unregulated tyrosine kinase activity. Much of the current development of anti-cancer therapies tries to target causative proteins in a specific manner to minimize side-effects. One attractive group of target proteins is the kinases. c-Kit is a receptor tyrosine kinase that normally controls the function of primitive hematopoietic cells, melanocytes and germ cells. It has become clear that uncontrolled activity of c-Kit contributes to formation of an array of human tumors. The unregulated activity of c-Kit may be due to overexpression, autocrine loops or mutational activation. This makes c-Kit an excellent target for cancer therapies in these tumors. In this review we will highlight the current knowledge on the signal transduction molecules and pathways activated by c-Kit under normal conditions and in cancer cells, and the role of aberrant c-Kit signaling in cancer progression. Recent advances in the development of specific inhibitors interfering with these signal transduction pathways will be discussed.
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Rönnstrand, LarsLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Experimental Clinical Chemistry, Dept. of Laboratory Medicine, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden(Swepub:lu)klke-lro
(författare)
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Uppsala universitetLudwiginstitutet för cancerforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Current Cancer Drug Targets6:1, s. 65-751568-00961873-5576
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