Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues

Addresses: Hogberg M, Medivir AB, Lunastigen 7, S-14144 Huddinge, Sweden. Medivir AB, S-14144 Huddinge, Sweden. Karolinska Inst, Ctr Microbiol & Tumor Biol, MTC, Stockholm, Sweden. Uppsala Univ, Dept Mol Biol, S-75124 Uppsala, Sweden.
The further development-of allosteric HIV-1 RT inhibitors in the urea analogue series of PETT (phenylethylthiazolylthiourea) derivatives is described here. The series includes derivatives with an ethyl linker (1-5) and racemic (6-16) and enantiomeric (17-

IMMUNODEFICIENCY-VIRUS TYPE-1; NONNUCLEOSIDE INHIBITORS; WILD-TYPE; POTENT; DERIVATIVES; REPLICATION; COMBINATION; NEVIRAPINE; DRUG; ZIDOVUDINE

Sahlberg, C (author)
Engelhardt, P (author)
Noreen, R (author)
Kangasmetsa, J (author)
Johansson, NG (author)
Oberg, B (author)
Vrang, L (author)
Zhang, H (author)
Sahlberg, BL (author)
Unge, TUppsala universitet,Strukturell molekylärbiologi(Swepub:uu)torsunge (author)
Lovgren, S (author)
Fridborg, K (author)
Backbro, KUppsala universitet,Strukturell molekylärbiologi(Swepub:uu)kba11612 (author)
Uppsala universitetStrukturell molekylärbiologi (creator_code:org_t)

By the author/editor: Hogberg, M; Sahlberg, C; Engelhardt, P; Noreen, R; Kangasmetsa, J; Johansson, NG; show more...; Oberg, B; Vrang, L; Zhang, H; Sahlberg, BL; Unge, T; Lovgren, S; Fridborg, K; Backbro, K; show less...

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