Synonymous nucleotide divergence and saturation: Effects of site-specific variations in codon bias and mutation rates

• The synonymous divergence between Escherichia coli and Salmonella typhimurium is explained in a model where there is a large variation between mutation rates at different nucleotide sites in the genome. The model is based on the experimental observation t

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mutation rates; codon bias; synonymous divergence; saturation; ESCHERICHIA-COLI; SUBSTITUTION RATES; PHYLOGENETIC ESTIMATION; SEQUENCE DIVERGENCE; DNA-SEQUENCES; GENES; SELECTION; REPAIR; EVOLUTION; BACTERIA

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