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- Wålinder, RobertUppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård (author)
Acute effects of a fungal volatile compound
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Environmental Health Perspectives,2005
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-79672
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79672URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1946981URI
- https://doi.org/10.1289/ehp.8193DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- OBJECTIVE: 3-Methylfuran (3-MF) is a common fungal volatile product with active biologic properties, and previous studies have indicated a contribution to airway disease. The aim of the present study was to assess the acute health effects of this compound in humans. DESIGN: Acute effects were assessed via chamber exposure to (1 mg/m3) 3-MF. PARTICIPANTS AND MEASUREMENTS: Twenty-nine volunteers provided symptom reports, ocular electromyograms, measurement of eye tear film break-up time,vital staining of the eye, nasal lavage, acoustic rhinometry, transfer tests, and dynamic spirometry. RESULTS: No subjective ratings were significantly increased during exposure. Blinking frequency and the lavage biomarkers myeloperoxidase and lysozyme were significantly increased, and forced vital capacity was significantly decreased during exposure to 3-MF compared with air control. CONCLUSIONS AND RELEVANCE TO CLINICAL PRACTICE: Acute effects in the eyes, nose, and airways were detected and might be the result of the biologically active properties of 3-MF. Thus, 3-MF may contribute to building-related illness.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Ernstgård, LenaKarolinska Institutet (author)
- Johanson, GunnarKarolinska Institutet (author)
- Norbäck, DanUppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för neurovetenskap,Eva Vingård(Swepub:uu)dagnorba (author)
- Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)pervenge (author)
- Wieslander, GunillaUppsala universitet,Institutionen för medicinska vetenskaper,Eva Vingård(Swepub:uu)guniwies (author)
- Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Related titles
- In:Journal of Environmental Health Perspectives: Environmental Health Perspectives113:12, s. 1775-17780091-67651552-9924
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16330362&dopt=Citation
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314919/pdf/ehp0113-001775.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-79672
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1946981
- https://doi.org/10.1289/ehp.8193
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