Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

Nyckelord

Animals

Apoptosis/*drug effects

Blotting; Western

Cell Separation

Cells; Cultured

Cytokines/*pharmacology

Dose-Response Relationship; Drug

Enzyme Activation/drug effects

Enzyme Inhibitors/pharmacology

Humans

Insulin/secretion

Insulin-Secreting Cells/*drug effects/secretion

MAP Kinase Kinase 4/*genetics

Mice

Mitogen-Activated Protein Kinases/metabolism

NG-Nitroarginine Methyl Ester/pharmacology

Nitric Oxide/*physiology

Nitric Oxide Donors/pharmacology

Nitric Oxide Synthase Type II/antagonists & inhibitors

Oncogene Protein v-akt/*genetics

Research Support; Non-U.S. Gov't

S-Nitroso-N-Acetylpenicillamine/pharmacology

Signal Transduction

p38 Mitogen-Activated Protein Kinases/metabolism

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