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- Lindkvist, AnnaUppsala universitet,Institutionen för genetik och patologi (author)
Differential effects of TGF-beta1 on telomerase activity in thyroid carcinoma cells
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Elsevier BV,2005
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-80318
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-80318URI
- https://doi.org/10.1016/j.bbrc.2005.10.131DOI
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- Language:English
- Summary in:English
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Notes
- The aim of the present study was to investigate the effect of transforming growth factor-beta1 (TGF-beta1) on telomerase activity in a panel of human anaplastic thyroid carcinoma (ATC) cell lines. Addition of TGF-beta1 decreased the telomerase activity in HTh 74 and KTC-1 cells, while in C 643 and HTh 7 an increased activity was observed. The decreased telomerase activity appeared to be due to transcriptional repression of the hTERT promoter. Addition of a PI-3 kinase inhibitor (LY294002) abrogated the stimulatory effect of TGF-beta1 on the telomerase activity, indicating the possible involvement of hTERT activation via phosphorylation. Furthermore, the MEK-inhibitor U0126 had similar effects suggesting dual regulatory mechanisms. Interestingly, the cell lines differed genetically in that ATC cell lines responding with increased telomerase activity harbored a p53 mutation. In conclusion, TGF-beta1 exerts opposing effects on telomerase activity in ATC cell lines, possibly reflecting deregulation of TGF-beta1 signaling in a more malignant genotype.
Subject headings and genre
- Anaplastic thyroid carcinoma
- c-Myc
- hTERT promoter
- p53
- Telomerase
- TGF-β1
Added entries (persons, corporate bodies, meetings, titles ...)
- Franzén, ÅsaUppsala universitet,Institutionen för genetik och patologi (author)
- Ren, Zhi-PingUppsala universitet,Institutionen för genetik och patologi (author)
- Heldin, Nils-ErikUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)neheldin (author)
- Paulsson-Karlsson, YlvaUppsala universitet,Institutionen för genetik och patologi (author)
- Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)
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- In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV338:3, s. 1625-16330006-291X1090-2104
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