Divergent patterns of recent retroviral integrations in the human and chimpanzee genomes: probable transmissions between other primates and chimpanzees

Jern, PatricUppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för medicinsk biokemi och mikrobiologi,Blomberg (författare)

Divergent patterns of recent retroviral integrations in the human and chimpanzee genomes : probable transmissions between other primates and chimpanzees

The human genome is littered by endogenous retrovirus sequences (HERVs), which constitute up to 8% of the total genomic sequence. The sequencing of the human (Homo sapiens) and chimpanzee (Pan troglodytes) genomes has facilitated the evolutionary study of ERVs and related sequences. We screened both the human genome (version hg16) and the chimpanzee genome (version PanTro1) for ERVs and conducted a phylogenetic analysis of recent integrations. We found a number of recent integrations within both genomes. They segregated into four groups. Two larger gammaretrovirus-like groups (PtG1 and PtG2) occurred in chimpanzees but not in humans. The PtG sequences were most similar to two baboon ERVs and a macaque sequence but neither to other chimpanzee ERVs nor to any human gammaretrovirus-like ERVs. The pattern was consistent with cross-species transfer via predation. This appears to be an example of horizontal transfer of retroviruses with occasional fixation in the germ line.

Sperber, GöranUppsala universitet,Institutionen för neurovetenskap,Sperber(Swepub:uu)gsp26613 (författare)
Blomberg, JonasUppsala universitet,Institutionen för medicinska vetenskaper,Blomberg(Swepub:uu)jonablom (författare)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.