NEW DHFRVIII TRIMETHOPRIM-RESISTANCE GENE, FLANKED BY IS26, WHOSE PRODUCT IS REMOTE FROM OTHER DIHYDROFOLATE REDUCTASES IN PARSIMONY ANALYSIS

• A new plasmid-borne gene, dhfrVIII, encoding high-level trimethoprim resistance (Tp(R)) was found in an intestinal Escherichia coli. It seems to be a widely occurring mediator of Tp(R). Among 973 examined Tp(R) E. coli, the new resistance gene was found i

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TRANSPOSABLE ELEMENT; ANTIBIOTICS; CONJUGATIVE PLASMID PLM0226; PHYLOGENY ANALYSIS; DHFR; NUCLEOTIDE-SEQUENCE ANALYSIS; AMINO-ACID-SEQUENCE; ESCHERICHIA-COLI; DNA-SEQUENCE; PLASMID R67; ELEMENT; SITE; BORNE; TN7; TRANSPOSITION

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