Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?

• This study was designed to test the hypothesis that relaxin stimulates bone resorption by regulating the production of several mediators that stimulate osteoclast formation. The levels of mediators were measured in response to differing relaxin concentrations in supernatants from peripheral blood mononuclear cells (PBMCs), MCF-7 breast cancer cells, and normal human osteoblasts. Although all cell types expressed mRNA for the relaxin receptor (LGR7), only PBMCs responded to relaxin at physiologic levels by increasing tumor necrosis factor-α and interleukin-1β secretion. The findings indicate that PBMCs should be studied in relation to the effect of relaxin on inflammation and bone destruction caused by osteoclasts.

Keyword

Bone Resorption/*metabolism/*pathology

Cells; Cultured

Humans

Inflammation Mediators/metabolism

Interleukin-1/*secretion

Monocytes/*drug effects/metabolism

Relaxin/*pharmacology

Tumor Necrosis Factor-alpha/*secretion

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

art (subject category)