Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

• Nuclear receptors regulate metabolic pathways in response to changes in the environment by appropriate alterations in gene expression of key metabolic enzymes, Here, a computational search approach based on iteratively built hidden Markov models of nuclea

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HIDDEN MARKOV-MODELS; PRIMARY CULTURES; BOVINE LIVER; FATTY-ACIDS; ACTIVATION; ALPHA; GENE; SUPERFAMILY; EXPRESSION; GAMMA

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