Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis

• Immunization of mice with rat type II collagen (CII), a cartilage-specific protein, leads to development of collagen-induced arthritis (CIA), a model for rheumatoid arthritis. To define the interaction between the immune system and cartilage, we produced

Nyckelord

collagen-induced arthritis; T-cell tolerance; transgenic mice; autoimmunity; rheumatoid arthritis; MAJOR HISTOCOMPATIBILITY COMPLEX; TRANSGENIC MICE; RHEUMATOID-ARTHRITIS; SELF-TOLERANCE; GENE; MOUSE; AUTOIMMUNITY; ASSOCIATION; CHONDRODYSPLASIA; IDENTIFIC

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