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  • Aulchenko, Yurii S (author)

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2008-12-07
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-86913
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-86913URI
  • https://doi.org/10.1038/ng.269DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118088730URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 x 10(-8)), including 16 loci that were identified by previous GWA studies. The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)). For three loci, effect sizes differed significantly by sex. Genetic risk scores based on lipid loci explain up to 4.8% of variation in lipids and were also associated with increased intima media thickness (P = 0.001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors.

Subject headings and genre

  • MEDICINE
  • MEDICIN
  • Genetics
  • Genetik

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ripatti, Samuli (author)
  • Lindqvist, Ida (author)
  • Boomsma, Dorret (author)
  • Heid, Iris M (author)
  • Pramstaller, Peter P (author)
  • Penninx, Brenda W J H (author)
  • Janssens, A Cecile J W (author)
  • Wilson, James F (author)
  • Spector, Tim (author)
  • Martin, Nicholas G (author)
  • Pedersen, Nancy LKarolinska Institutet (author)
  • Kyvik, Kirsten Ohm (author)
  • Kaprio, Jaakko (author)
  • Hofman, Albert (author)
  • Freimer, Nelson B (author)
  • Jarvelin, Marjo-Riitta (author)
  • Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll (author)
  • Campbell, Harry (author)
  • Rudan, Igor (author)
  • Johansson, ÅsaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)asjoh108 (author)
  • Marroni, Fabio (author)
  • Hayward, Caroline (author)
  • Vitart, Veronique (author)
  • Jonasson, IngerUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ingejona (author)
  • Pattaro, Cristian (author)
  • Wright, Alan (author)
  • Hastie, Nick (author)
  • Pichler, Irene (author)
  • Hicks, Andrew A (author)
  • Falchi, Mario (author)
  • Willemsen, Gonneke (author)
  • Hottenga, Jouke-Jan (author)
  • de Geus, Eco J C (author)
  • Montgomery, Grant W (author)
  • Whitfield, John (author)
  • Magnusson, PatrikKarolinska Institutet (author)
  • Saharinen, Juha (author)
  • Perola, Markus (author)
  • Silander, Kaisa (author)
  • Isaacs, Aaron (author)
  • Sijbrands, Eric J G (author)
  • Uitterlinden, Andre G (author)
  • Witteman, Jacqueline C M (author)
  • Oostra, Ben A (author)
  • Elliott, Paul (author)
  • Ruokonen, Aimo (author)
  • Sabatti, Chiara (author)
  • Gieger, Christian (author)
  • Meitinger, Thomas (author)
  • Kronenberg, Florian (author)
  • Döring, Angela (author)
  • Wichmann, H-Erich (author)
  • Smit, Johannes H (author)
  • McCarthy, Mark I (author)
  • van Duijn, Cornelia M (author)
  • Peltonen, Leena (author)
  • Karolinska InstitutetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC41:1, s. 47-551061-40361546-1718

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