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Markers of respirat...
Markers of respiratory inflammation in horses in relation to seasonal changes in air quality in a conventional racing stable
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Riihimäki, Miia (författare)
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- Raine, Amanda (författare)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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- Elfman, Lena (författare)
- Uppsala universitet,Arbets- och miljömedicin,Eva Vingård
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visa fler...
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Pringle, John (författare)
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visa färre...
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Canadian Journal of Veterinary Research-Revue Canadienne de Recherche Veterinaire. - 0830-9000. ; 72:5, s. 432-439
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Airborne factors in a conventionally managed racing stable and markers of pulmonary inflammation in the stabled horses were investigated on 3 occasions at 6-month intervals, including 2 winter periods and the intervening summer period. The stable measurements included inside and outside ambient temperature and relative humidity, levels of total and respirable dust, endotoxin, and 1,3-beta-glucan. Horses (n = 12) were examined in detail clinically as well as by endoscopy, bronchoalveolar lavage (BAL) cytology, and real-time polymerase chain reaction (RT-PCR) analysis of BAL-cells for IL-6 and IL-10 mRNA. Indoor measurements showed low dust levels irrespective of season. Inhalable dust, as well as 1,3-beta-glucan, were higher during the winter stabling period, whereas endotoxin levels were higher during summer. Complete data from all sampling occasions to be used for further evaluation was obtained for only 8 of the horses. There was a trend for elevation of BAL neutrophils in the horses during winter stabling that coincided with a 3.7-fold increased expression of IL-6 mRNA in BAL cells (P = 0.014). Compared to summer sampling, IL-10 mRNA expression was significantly upregulated in only 1 of the winter sampling occasions, implicating influence on immune regulation by factor/s apart from seasonal differences. Our findings suggest up-regulation of innate immunity in the airways of stabled horses; in particular involving IL-6 in association with mild elevations in respirable dust, 1,3-beta-glucan, and/or cold ambient air. However, given that this study was observational, other unmeasured environmental factors associated with winter stabling need to be considered.
Ämnesord
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
Nyckelord
- VETERINARY MEDICINE
- VETERINÄRMEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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