WFRF:(Svedlund Jessica)
Search: WFRF:(Svedlund Jessica) > (2009) > The internally trun...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Björklund, PeymanUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery (author)
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009-01-22
- Public Library of Science (PLoS),2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-88392
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-88392URI
- https://doi.org/10.1371/journal.pone.0004243DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- BACKGROUND: Breast cancer is a common malignant disease, which may be caused by a number of genes deregulated by genomic or epigenomic events. Deregulated WNT/beta-catenin signaling with accumulation of beta-catenin is common in breast tumors, but mutations in WNT signaling pathway components have been rare. An aberrantly spliced internally truncated LRP5 receptor (LRP5Delta666-809, LRP5Delta) was shown recently to be resistant to DKK1 inhibition, and was required for beta-catenin accumulation in hyperparathyroid tumors and parathyroid tumor growth. METHODOLOGY/PRINCIPAL FINDINGS: Here we show, by reverse transcription PCR and Western blot analysis, that LRP5Delta is frequently expressed in breast tumors of different cancer stage (58-100%), including carcinoma in situ and metastatic carcinoma. LRP5Delta was required in MCF7 breast cancer cells for the non-phosphorylated active beta-catenin level, transcription activity of beta-catenin, cell growth in vitro, and breast tumor growth in a xenograft SCID mouse model. WNT3 ligand, but not WNT1 and WNT3A augmented the endogenous beta-catenin activity of MCF7 cells in a DKK1-insensitive manner. Furthermore, an anti-LRP5 antibody attenuated beta-catenin activity, inhibited cell growth, and induced apoptosis in LRP5Delta-positive MCF7 and T-47D breast cancer cells, but not in control cells. CONCLUSIONS/SIGNIFICANCE: Our results suggest that the LRP5Delta receptor is strongly implicated in mammary gland tumorigenesis and that its aberrant expression present an early event during disease progression. LRP5 antibody therapy may have a significant role in the treatment of breast cancer.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Svedlund, JessicaUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)jessv142 (author)
- Olsson, Anna-KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)annaolss (author)
- Åkerström, GöranUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)goranas (author)
- Westin, GunnarUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)gunnwest (author)
- Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
Related titles
- In:PloS one: Public Library of Science (PLoS)4:1, s. e4243-1932-6203
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Björklund, Peyma ...
- Svedlund, Jessic ...
- Olsson, Anna-Kar ...
- Åkerström, Göran
- Westin, Gunnar
- Articles in the publication
- PloS one
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
