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Increased risk of r...
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Holmberg, LarsUppsala universitet,Endokrinkirurgi
(author)
Increased risk of recurrence after hormone replacement therapy in breast cancer survivors
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-03-25
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Oxford University Press (OUP),2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-89229
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89229URI
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https://doi.org/10.1093/jnci/djn058DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116828651URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-42212URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Hormone replacement therapy (HT) is known to increase the risk of breast cancer in healthy women, but its effect on breast cancer risk in breast cancer survivors is less clear. The randomized HABITS study, which compared HT for menopausal symptoms with best management without hormones among women with previously treated breast cancer, was stopped early due to suspicions of an increased risk of new breast cancer events following HT. We present results after extended follow-up. METHODS: HABITS was a randomized, non-placebo-controlled noninferiority trial that aimed to be at a power of 80% to detect a 36% increase in the hazard ratio (HR) for a new breast cancer event following HT. Cox models were used to estimate relative risks of a breast cancer event, the maximum likelihood method was used to calculate 95% confidence intervals (CIs), and chi(2) tests were used to assess statistical significance, with all P values based on two-sided tests. The absolute risk of a new breast cancer event was estimated with the cumulative incidence function. Most patients who received HT were prescribed continuous combined or sequential estradiol hemihydrate and norethisterone. RESULTS: Of the 447 women randomly assigned, 442 could be followed for a median of 4 years. Thirty-nine of the 221 women in the HT arm and 17 of the 221 women in the control arm experienced a new breast cancer event (HR = 2.4, 95% CI = 1.3 to 4.2). Cumulative incidences at 5 years were 22.2% in the HT arm and 8.0% in the control arm. By the end of follow-up, six women in the HT arm had died of breast cancer and six were alive with distant metastases. In the control arm, five women had died of breast cancer and four had metastatic breast cancer (P = .51, log-rank test). CONCLUSION: After extended follow-up, there was a clinically and statistically significant increased risk of a new breast cancer event in survivors who took HT.
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Iversen, Ole-Erik
(author)
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Rudenstam, Carl Magnus
(author)
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Hammar, Mats,1950-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Obstetrik och gynekologi,Kvinnokliniken i Linköping(Swepub:liu)matha92
(author)
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Kumpulainen, Eero
(author)
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Jaskiewicz, Janusz
(author)
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Jassem, Jacek
(author)
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Dobaczewska, Daria
(author)
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Fjosne, Hans E.
(author)
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Peralta, Octavio
(author)
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Arriagada, RodrigoKarolinska Institutet
(author)
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Holmqvist, Marit
(author)
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Maenpa, Johanna
(author)
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Uppsala universitetEndokrinkirurgi
(creator_code:org_t)
Related titles
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In:Journal of the National Cancer Institute: Oxford University Press (OUP)100:7, s. 475-4820027-88741460-2105
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Holmberg, Lars
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Iversen, Ole-Eri ...
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Hammar, Mats, 19 ...
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Jassem, Jacek
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Dobaczewska, Dar ...
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Fjosne, Hans E.
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Peralta, Octavio
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Holmqvist, Marit
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Maenpa, Johanna
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Linköping University