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The effect of a mix...
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Steer, PeterUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
The effect of a mixed meal on endothelium-dependent vasodilation is dependent on fat content in healthy humans
- Artikel/kapitelEngelska2003
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-90413
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-90413URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Impaired endothelium-dependent vasodilation (EDV) is an early marker of atherosclerosis. The aim of the present study was to investigate how meals with different fat contents influence endothelial vasodilatory function. A total of 26 young, healthy men and women aged 20-30 years ingested an ordinary Western meal [34 energy% (E%) fat, n =10], or isocaloric meals with low-fat (20 E%, n =8), or minimal-fat (3 E%, n =8) content. EDV was assessed as forearm blood flow (FBF) during local administration of 4 microg/min methacholine chloride (Mch-FBF) and endothelium-independent vasodilation as FBF during administration of 10 microg/min sodium nitroprusside (SNP-FBF) at baseline and 1 and 2 h after each meal. FBF was determined by venous occlusion plethysmography. An endothelial function index (EFI) was calculated as the Mch-FBF/SNP-FBF ratio. Both Mch-FBF and the EFI were decreased at 1 h after the 34 E% fat meal ( P <0.01 and P <0.05 respectively), but approached fasting levels after 2 h. Mch-FBF and EFI did not change significantly in the group consuming the 20 E% fat meal, but increased in the 3 E% fat group ( P <0.01 and P <0.05 compared with baseline for Mch-FBF and EFI respectively). SNP-FBF was not significantly affected by any of the meals. In conclusion, low-fat meals did not attenuate EDV, in contrast with an ordinary Western meal, which transiently impaired EDV. Our findings indicate that a dietary fat content of 20 E% or less might be beneficial to endothelial vasodilatory function.
Ämnesord och genrebeteckningar
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diet
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endothelium
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fatty acid
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insulin
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meal
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sarabi, Dennis M.Uppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Karlström, Brita
(författare)
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Basu, Samar
(författare)
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Berne, ChristianUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)chber255
(författare)
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Vessby, Bengt
(författare)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Science105:1, s. 81-870143-52211470-8736
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