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Extracellular signa...
Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons
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- Enarsson, Maria (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Erlandsson, Anna (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Larsson, Helena (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Forsberg-Nilsson, Karin (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Molecular Cancer Research. - 1541-7786 .- 1557-3125. ; 1:2, s. 147-154
- Related links:
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https://urn.kb.se/re...
Abstract
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- Knowledge about signaling pathways in response to external signals is needed to understand the regulation of stem cell proliferation and differentiation toward particular cell fates. The Ras/extracellular signal-regulated kinase (ERK) pathway has been suggested to play an essential role in neuronal differentiation. We have examined ERK signaling in the transition from multipotent stem cell to post-mitotic progeny using primary stem cells from the rat embryonic cortex. Fibroblast growth factor-2 (FGF-2) is a stem cell mitogen, whereas platelet-derived growth factor AA (PDGF-AA) expands a pool of committed neuronal precursors from stem cells. When comparing ERK activation by these growth factors, we found that FGF-2 stimulates high and PDGF-AA lower levels of ERK phosphorylation in stem cells. Differentiation was monitored as down-regulation of the bHLH transcription factor mammalian achaete-scute homologue-1 (MASH1). Even in the absence of active ERK, MASH1 became down-regulated and microtubule-associated protein 2-positive cells could form. Thus, ERK activation seems dispensable for the earliest steps of CNS stem cell differentiation.
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