SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Kelly Brendan)
 

Sökning: WFRF:(Kelly Brendan) > Aryl amino acetamid...

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

Dans, Madeline G. (författare)
Burnet Institute, VIC, Melbourne, Australia; Walter and Eliza Hall Institute, VIC, Parkville, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Boulet, Coralie (författare)
Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland
Watson, Gabrielle M. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
visa fler...
Nguyen, William (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Dziekan, Jerzy M. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Evelyn, Cindy (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Reaksudsan, Kitsanapong (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Mehra, Somya (författare)
Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
Razook, Zahra (författare)
Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
Geoghegan, Niall D. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Mlodzianoski, Michael J. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Goodman, Christopher Dean (författare)
School of Biosciences, The University of Melbourne, VIC, Parkville, Australia
Ling, Dawson B. (författare)
Burnet Institute, VIC, Melbourne, Australia
Jonsdottir, Thorey K. (författare)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden
Tong, Joshua (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia
Famodimu, Mufuliat Toyin (författare)
Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Kristan, Mojca (författare)
Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
Pollard, Harry (författare)
Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
Stewart, Lindsay B. (författare)
Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
Brandner-Garrod, Luke (författare)
Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
Sutherland, Colin J. (författare)
Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
Delves, Michael J. (författare)
Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
McFadden, Geoffrey I. (författare)
School of Biosciences, The University of Melbourne, VIC, Parkville, Australia
Barry, Alyssa E. (författare)
Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
Crabb, Brendan S. (författare)
Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; Monash University, VIC, Melbourne, Australia
de Koning-Ward, Tania F. (författare)
Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
Rogers, Kelly L. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Cowman, Alan F. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Tham, Wai-Hong (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Sleebs, Brad E. (författare)
Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
Gilson, Paul R. (författare)
Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia
visa färre...
 (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. Here, we select parasites resistant to M-833 and identify mutations in the START lipid transfer protein (PF3D7_0104200, PfSTART1). Introducing PfSTART1 mutations into wildtype parasites reproduces resistance to M-833 as well as to more potent analogues. PfSTART1 binding to the analogues is validated using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assays. Imaging of invading merozoites shows the inhibitors prevent the development of ring-stage parasites potentially by inhibiting the expansion of the encasing parasitophorous vacuole membrane. The PfSTART1-targeting compounds also block transmission to mosquitoes and with multiple stages of the parasite’s lifecycle being affected, PfSTART1 represents a drug target with a new mechanism of action.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy