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Synthesis and Radio...
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Ghirmai, SenaitUppsala universitet,Kemiska institutionen
(author)
Synthesis and Radioiodination of 7-(3´-Ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1), (ANC)
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2004-08-12
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Wiley,2004
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-91769
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-91769URI
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https://doi.org/10.1002/jlcr.840DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Derivatives of nido-carborate have potential use in tumour targeting as hydrophilic boron-rich compounds for boron neutron capture therapy (BNCT) and as pendant groups for attachment of radiohalogens to tumour-seeking molecules. For this purpose, functionalized derivatives of nido-carborates that can be conjugated to biomolecules should be synthesized and evaluated. In this study, racemic 1, 7-(3′-ammoniopropyl)-7,8-dicarba-nido-undecaborate(-1) (acronym ANC) was obtained by degradation of the corresponding aminopropyl-o-carborane, which was synthesized in three steps from 1-tert-butyldimethylsilyl-2-(3-bromopropyl)-o-carborane, with sodium hydroxide in absolute ethanol. The racemate 1 was radioiodinated (125I) using the Chloramine-T method. Radio-TLC results showed that radiolabelling with 125I was achieved in a yield greater than 95%.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Malmquist, JonasUppsala universitet,Kemiska institutionen
(author)
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Lundquist, HansUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
(author)
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Tolmachev, VladimirUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)vladtolm
(author)
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Sjöberg, StefanUppsala universitet,Kemiska institutionen(Swepub:uu)stefsjob
(author)
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Uppsala universitetKemiska institutionen
(creator_code:org_t)
Related titles
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In:Journal of labelled compounds & radiopharmaceuticals: Wiley47:9, s. 557-5690362-48031099-1344
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