Long-term imaging effects in rat liver after a single injection of an iron oxide nanoparticle based MR contrast agent

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Briley Saebo, KarenUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi (author)

Long-term imaging effects in rat liver after a single injection of an iron oxide nanoparticle based MR contrast agent

Article/chapterEnglish2004

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2004-09-23
Wiley,2004
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LIBRIS-ID:oai:DiVA.org:uu-91939
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-91939URI
https://doi.org/10.1002/jmri.20175DOI

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Language:English
Summary in:English

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PURPOSE: To investigate the duration of liver R2* enhancement and pharmacokinetics following administration of an iron oxide nanoparticle in a rat model.MATERIALS AND METHODS: Rats were injected with 0, 1, 2, or 5 mg Fe/kg of NC100150 Injection, and quantitative in vivo 1/T2* liver measurements were obtained between 1 and 133 days after injection. The concentration of NC100150 Injection was determined by relaxometry methods in ex vivo rat liver homogenate.RESULTS: At all dose levels, 1/T2* remained greater than control values up to 63 days after injection. In the highest dose group, 1/T2* was above control levels during the entire 133 day time-course investigated. There were no quantifiable amounts of NC100150 Injection present 63 days after injection in any of the dose groups. The half-life of NC100150 Injection in rat liver was dose dependent. For the lowest dose group, the degradation of the particles could be defined by a mono-exponential function with a half-life of eight days. For the 2 and 5 mg Fe/kg dose groups, the degradation was bi-exponential with a fast initial decay of seven to eight days followed by a slow terminal decay of 43-46 days.CONCLUSION: NC100150 Injection exhibits prolonged 1/T2* enhancement in rat liver. The liver enhancement persisted at time points when the concentration of iron oxide particles present in the liver was below method detection limits. The prolonged 1/T2* enhancement is likely a result of the particle breakdown products and the induction of ferritin and hemosiderin with increasing iron cores/loading factors.

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Hustvedt, Svein Olaf (author)
Haldorsen, Anita (author)
Bjørnerud, Atle (author)
Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

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In:Journal of Magnetic Resonance Imaging: Wiley20:4, s. 622-6311053-18071522-2586

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