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  • Ljungdahl, MikaelUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal surgery (author)

Inflammatory response in patients with malignant obstructive jaundice

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2009-07-08
  • Informa UK Limited,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-92557
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-92557URI
  • https://doi.org/10.1080/00365520600825190DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:14518127URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective. Surgery in patients with malignant obstructive jaundice is associated with increased risks for postoperative septic complications. The aim of this study was to investigate the inflammatory and the local cellular immune response in patients accepted for surgery because of tumours in the hepatic-pancreatic-biliary (HPB) tract. Material and methods. Patients with obstructive jaundice (group HPB+) were compared with those without (HPB-). Patients undergoing surgery for benign abdominal disorders served as controls. Obstructive jaundice was present in 18 out of 33 HPB patients. Preoperatively, blood was analysed for bacteria, endotoxins and cytokines (TNF-α, IL-6 and IL-10). At operation, mesenteric lymph nodes (MLNs) were excised for bacterial cultures using standard microbiological techniques, and immunohistochemistry, using antibodies CD4 and CD8 (mainly staining T lymphocytes), CD68 (macrophages), and anti-caspase-3 (to determine the rate of apoptosis). Results. Bacterial translocation was not demonstrated in any of the patients. Increased preoperative concentrations of endotoxins were found in group HPB+. The number of macrophages and the rate of apoptosis in MLNs were increased in jaundiced patients, while the number of T lymphocytes was decreased. Conclusions. Malignant obstructive jaundice causes increased blood concentrations of endotoxins and cytokines, an increased number of macrophages in MLNs, a higher rate of apoptosis in MLNs, but a decreased number of T lymphocytes in MLNs. The lymphocyte depletion is probably due to the increased rate of apoptosis, and might reduce the ability of jaundiced patients to eradicate infection.

Subject headings and genre

  • Apoptosis
  • bacterial translocation
  • cytokines
  • endotoxins
  • lymphocytes
  • obstructive jaundice
  • surgery
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Österberg, JohannaUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal surgery (author)
  • Ransjö, UlrikaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Engstrand, LarsKarolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larseng (author)
  • Haglund, UlfUppsala universitet,Institutionen för kirurgiska vetenskaper(Swepub:uu)ulfhagnd (author)
  • Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Gastroenterology: Informa UK Limited42:1, s. 94-1020036-55211502-7708

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