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Autologous and allo...
Autologous and allogeneic stem cell transplantation in adult ALL : The Swedish Adult ALL Group experience
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- Hallböök, Helene (author)
- Karolinska Institutet,Uppsala universitet,Hematologi
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Hägglund, Hans (author)
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Stockelberg, Dick (author)
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- Nilsson, Per-Gunnar (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Karlsson, Karin (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Björkholm, Magnus (author)
- Karolinska Institutet
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- Linderholm, Mats (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Wahlin, Anders (author)
- Umeå universitet,Medicin
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Linder, Olle (author)
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- Smedmyr, Bengt (author)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- 2005-04-18
- 2005
- English.
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In: Bone Marrow Transplantation. - London : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 35:12, s. 1141-1148
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Abstract
Subject headings
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- Adult patients with acute lymphoblastic leukaemia (ALL) have been treated according to national protocols in Sweden since 1986. Stem cell transplantation (SCT) has been recommended in first remission for patients with risk factors for relapse, and for standard risk patients only after relapse. In this retrospective study, the results of autologous and allogeneic SCT in these populations were evaluated. In total, 187 patients with a median age of 34 years (17-66 years) underwent SCT. The 5-year disease-free survival (DFS), for all patients, was 26% (Confidence intervals (CI) 20-32%). The 5-year DFS was higher for patients transplanted in first remission 32% (CI 24-40%) compared to 14% (CI 5-23%; P<0.0001) in patients transplanted beyond first remission. No significant differences in DFS (P=0.06) were determined between autologous, related donor and unrelated donor SCT in the whole cohort. A lower relapse rate was counterbalanced by higher treatment-related mortality in patients undergoing allogeneic SCT. In Philadelphia-positive ALL, allogeneic SCT was superior to autologous SCT, with a 5-year DFS of 30% (CI 12-47%) vs 0% (P=0.04). Limited chronic graft-versus-host-disease (GVHD) was associated with an improved DFS of 53% (CI 38-69%) compared to no chronic GVHD of 22% (CI 10-36%; P=0.0008), indicating a clinically important graft-versus-leukaemia effect.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Comparative Study
- Disease-Free Survival
- Female
- Graft vs Host Disease
- Graft vs Leukemia Effect
- Hematopoietic Stem Cell Transplantation/*methods
- Humans
- Leukemia; Lymphocytic; Acute; L2/*therapy
- Male
- Middle Aged
- Philadelphia Chromosome
- Probability
- Recurrence
- Retrospective Studies
- Sweden
- Tissue Donors
- Transplantation; Autologous
- Transplantation; Homologous
- stem cell transplantation
- acute lymphoblastic leukaemia
- adults
- versus host disease
- graft
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hallböök, Helene
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Hägglund, Hans
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Stockelberg, Dic ...
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Nilsson, Per-Gun ...
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Karlsson, Karin
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Björkholm, Magnu ...
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show more...
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Linderholm, Mats
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Wahlin, Anders
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Linder, Olle
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Smedmyr, Bengt
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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Uppsala University
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Umeå University
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Lund University
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Karolinska Institutet
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Linköping University