T-cell inhibition does not aggravate bacterial translocation from rat small bowel

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: L773:0966 3274 OR L773:1878 5492 > T-cell inhibition d...

Stenbäck, AndersUppsala universitet,Transplantationskirurgi,Barnkirurgi (författare)

T-cell inhibition does not aggravate bacterial translocation from rat small bowel

Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

Elsevier BV,2006
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-93479
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-93479URI
https://doi.org/10.1016/j.trim.2006.09.024DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Background: T-cell mediated immunity has been proposed to have an important function in the defence against translocating microbes from the gastrointestinal tract. After small bowel transplantation massive T-cell immunosuppression is necessary to avoid rejection. As a consequence, infections with intestinal bacteria are the main contributors to mortality in this setting. This could further imply that T cells are important in limiting bacterial translocation. In a model for bacterial translocation from small bowel in the rat we examined the outcome of T-cell inactivation. Methods: The studies were performed in a model of bacterial translocation from a Thiry-Vella loop of small bowel in the rat. The animals were treated with an anti-α/β T-cell receptor monoclonal antibody (R73). Inhibition of T-cell activation was also made using the immunosuppressive drug cyclosporin A. All animals were sacrificed on day 3 postoperatively and translocation to the mesenteric lymph nodes, liver, spleen, lung and blood was evaluated. Results: Treatment with R73 resulted in an almost complete labelling of T cells but did not result in any increased bacterial translocation compared to animals treated with saline. Neither did immunosuppression with cyclosporin A. Conclusions: In the model of bacterial translocation from a defunctionalised loop of small bowel the inhibition of T cells does not increase bacterial translocation to mesenteric lymph nodes or promote the systemic spread of the translocating bacteria. This indicates that T cells do not have any important protective function against translocating microbes from defunctionalised small bowel.

Ämnesord och genrebeteckningar

Cyclosporin
Defunctionalised bowel
Mucosal barrier
R73
Small bowel transplantation
Thiry-Vella loop
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lorant, TomasUppsala universitet,Transplantationskirurgi(Swepub:uu)tomalora (författare)
Meurling, StaffanUppsala universitet,Barnkirurgi (författare)
Johnsson, CeciliaUppsala universitet,Transplantationskirurgi(Swepub:uu)cecijohn (författare)
Uppsala universitetTransplantationskirurgi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Transplant Immunology: Elsevier BV16:3-4, s. 208-2140966-32741878-5492

Internetlänk

Hitta via bibliotek

Transplant Immunology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Stenbäck, Anders; Lorant, Tomas; Meurling, Staffa ...; Johnsson, Cecili ...

Artiklar i publikationen: Transplant Immun ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se