SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Edwards Joanne)
 

Sökning: WFRF:(Edwards Joanne) > Tc-99m-NC100668, a ...

  • Edwards, DavidUppsala universitet,Enheten för radiologi,Ahlström (författare)

Tc-99m-NC100668, a new tracer for imaging venous thromboemboli : pre-clinical biodistribution and incorporation into plasma clots in vivo and in vitro

  • Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

  • 2006-06-28
  • Springer Science and Business Media LLC,2006
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-95163
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95163URI
  • https://doi.org/10.1007/s00259-006-0091-9DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose: Tc-99m-NC100668 is a new radiotracer being developed to aid the diagnosis of thromboembolism. The structure of NC100668 is similar to a region of human alpha(2)-antiplasmin, which is a substrate for factor XIIIa (FXIIIa). The purpose of this study was to confirm the uptake of Tc-99m-NC100668 into forming plasma clot and to establish the biodistribution of Tc-99m-NC100668 in Wistar rats. Methods: The in vitro plasma clot uptake of Tc-99m-NC100668 and other compounds with known affinities to FXIIIa was measured using a plasma clot assay. The biodistribution and blood clot uptake of radioactivity of Tc-99m-NC100668 in normal Wistar rats and those bearing experimentally induced deep vein thrombi were investigated. Results: The in vitro uptake of Tc-99m-NC100668 was greater than that for [C-14] dansyl cadaverine, a known substrate of FXIIIa in the plasma clot assay. The biodistribution of Tc-99m-NC100668 in male and female Wistar rats up to 24 h p.i. showed that radioactivity was rapidly excreted, predominantly into the urine, with very little background tissue retention. In vivo the uptake and retention of Tc-99m-NC100668 into the blood clot was greater than could be accounted for by non-specific accumulation of the radiotracer within the blood clot. Conclusion: Tc-99m-NC100668 was retained by plasma clots in vitro and blood clots in vivo. No significant tissue retention which could interfere with the ability to image thrombi in vivo was observed. This evidence suggests that Tc-99m-NC100668 might be useful in the detection of thromboembolism.

Ämnesord och genrebeteckningar

  • biodistribution
  • molecular imaging
  • Tc-99m-NC100668
  • thrombus
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lewis, Joanne (författare)
  • Lear, Rochelle (författare)
  • Battle, Mark (författare)
  • Godden, Vanessa (författare)
  • Farrar, Gill (författare)
  • Barnett, D. Jon (författare)
  • Oliveira, Alexandra (författare)
  • Coombes, Catherine (författare)
  • Ahlström, HåkanUppsala universitet,Enheten för radiologi,Ahlström(Swepub:uu)hakanahl (författare)
  • Uppsala universitetEnheten för radiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC33:11, s. 1258-12651619-70701619-7089

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy