Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland

Persdotter Hedlund, GabriellaUppsala universitet,Institutionen för fysiologi (author)

Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells. No staining was found in the pancreas, which is in contrast to what has been described in the human.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
rat; fetal antigen 1 (FA1); epidermal growth factor (EGF); delta-like cDNA; adrenal-specific cDNA; preadipocyte factor 1 (Pref-1); zona glomerulosa-specific factor (ZOG); localisation; adrenal gland; pituitary gland; hypophysis; ovary

Carlsson, Hans-ErikUppsala universitet,Institutionen för fysiologi (author)
Shieck, EliseUppsala universitet,Institutionen för fysiologi (author)
Nilsson, IngridUppsala universitet,Institutionen för fysiologi (author)
Lundblad, CorneliaLund University,Lunds universitet,Uppsala universitet,Institutionen för fysiologi,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)mphy-cld (author)
Arons, SaraUppsala universitet,Institutionen för fysiologi (author)
Iversen, Anna-KarinUppsala universitet,Institutionen för fysiologi (author)
Looman, CamillaUppsala universitet,Institutionen för fysiologi (author)
Jensen, H.E.Uppsala universitet,Institutionen för fysiologi (author)
Hau, JannUppsala universitet,Institutionen för fysiologi (author)
Uppsala universitetInstitutionen för fysiologi (creator_code:org_t)

By the author/editor: Persdotter Hedlu ...; Carlsson, Hans-E ...; Shieck, Elise; Nilsson, Ingrid; Lundblad, Cornel ...; Arons, Sara; show more...; Iversen, Anna-Ka ...; Looman, Camilla; Jensen, H.E.; Hau, Jann; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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