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Effects on blood co...
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Christensen, KjeldUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
(författare)
Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
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2009-07-07
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Informa UK Limited,2006
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-95970
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95970URI
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https://doi.org/10.1080/09537100600746557DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The effect of the direct platelet P2Y12 receptor inhibitor, AR-C69931MX, on activation of blood induced by stents with and without heparin coating was investigated using a whole blood Chandler loop model in vitro . Stents were deployed in Chandler loops. Fresh human blood with heparin and AR-C69931MX was rotated for 1 h at 37°C and used for measurements of platelets, microparticles, thrombin-antithrombin complex (TAT), fibrinogen binding to platelets, P-selectin expression by platelets, CD11b, Prothrombin Fragment F1+2, FXIa-AT, FXIIa-AT, C3a, sC5b-9 and stent score. In the first experiment there were four study groups with unmodified stents: 1a, no AR-C69931MX; 1b, 250 nmol/L; 1c, 750 nmol/L; 1d, 2250 nmol/L of AR-C69931MX. In the second experiment the concentration of AR-C69931MX was 500 nmol/L: 2a; tubings without stent; 2b; tubings with heparin-coated stent; 2c; tubings with unmodified stents. Heparin-coated stents were used in the third experiment: 3a; no AR-C69931MX; 3b; 500 nmol/L of AR-C69931MX. In the first experiment there were significant differences in all parameters analysed except for C3a, and stent score when the group with no AR-C69931MX was compared to all the groups with AR-C69931MX. In the second experiment there were significant differences in platelet count, TAT, FXIa-AT, FXIIa-AT and stent score when unmodified stents were compared to loops with no stents and partly to loops with heparin-coated stents. In the third experiment there was a significant reduction in generation of TAT, stent score and better preservation of platelet number by combining the platelet inhibitor and heparin-coated stents as compared to heparin-coated stents alone. The conclusion is that the direct P2Y12 receptor inhibitor AR-C69931MX reduced the different aspects of activation of blood induced by both unmodified and heparin-coated stents.
Ämnesord och genrebeteckningar
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Heparin coating
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Platelets
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Purin receptor blockade
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Stents
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Larsson, RolfUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)rolflars
(författare)
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Emanuelsson, Håkan
(författare)
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Elgue, GracielaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)gracelgu
(författare)
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Larsson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Biokemisk struktur och funktion(Swepub:uu)andlarss
(författare)
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Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Platelets: Informa UK Limited17:5, s. 318-3270953-71041369-1635
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