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- Björklund, PeymanUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery (author)
Activated β-catenin in the novel human parathyroid tumor cell line sHPT-1
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Elsevier BV,2007
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-96472
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-96472URI
- https://doi.org/10.1016/j.bbrc.2006.11.056DOI
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- Language:English
- Summary in:English
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Notes
- Misregulation of the Wnt/beta-catenin signalling pathway is involved in the development and progression of many cancers. Recently, we presented evidence for aberrant accumulation of non-phosphorylated (stabilized) beta-catenin in benign parathyroid tumors from patients with primary hyperparathyroidism (pHPT) or HPT secondary to uremia (sHPT). Here we have used a human parathyroid hormone (PTH)-producing cell line (sHPT-1), established from a hyperplastic parathyroid gland removed at operation of a patient with sHPT, to further investigate the potential importance of beta-catenin in parathyroid tumorigenesis. Our studies demonstrate that efficient and specific knockdown of beta-catenin by small interfering RNA (siRNA) markedly decreased endogenous beta-catenin transcriptional activity as well as expression of the Wnt/beta-catenin target genes cyclin D1 and c-myc, known to be overexpressed in a substantial fraction of parathyroid tumors. Furthermore, siRNA to beta-catenin inhibited cellular growth and induced cell death. Growth and survival of the parathyroid tumor cells are thus dependent on maintained expression level of beta-catenin. The Wnt/beta-catenin signalling pathway, and beta-catenin in particular, presents a potential therapeutic target for HPT.
Subject headings and genre
- β-Catenin
- c-myc
- Cyclin D1
- Hyperparathyroidism
- Parathyroid cell line
- Wnt signalling
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Åkerström, GöranUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)goranas (author)
- Westin, GunnarUppsala universitet,Institutionen för kirurgiska vetenskaper,Endokrinkirurgi, Endocrine Surgery(Swepub:uu)gunnwest (author)
- Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
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- In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV352:2, s. 532-5360006-291X1090-2104
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