A particle rearrangement index based on the Kawakita powder compression equation

In this article, the effect of original particle size on the Kawakita parameters, denoted a and b, has been studied using four model materials of different compression mechanics. It was found that fine powders, possibly showing significant particle rearrangement at low compression pressures, showed low values of parameter b(-1) and high values of parameter a. It is thus proposed that the product of these parameters is an indication of the overall contribution of particle rearrangement to the compression profile. Above a critical original particle size of a powder, particle rearrangement is negligible for the overall compression profile and below this critical particle size, particle rearrangement becomes significant. A critical particle size of about 40 microm was obtained. A classification of powders into groups dependent on the incidence of particle rearrangement is discussed and it is suggested that a rearrangement index and a classification system could be used as tools to enable rational interpretations of global compression parameters.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
Powder compression
Kawakita parameters
particle rearrangement
rearrangement index
powder compression classification system
PHARMACY
FARMACI

Klevan, IngvildUppsala universitet,Institutionen för farmaci (författare)
Alderborn, GöranUppsala universitet,Institutionen för farmaci(Swepub:uu)anald021 (författare)
Uppsala universitetInstitutionen för farmaci (creator_code:org_t)

Ingår i:Journal of Pharmaceutical Sciences: Elsevier BV98:3, s. 1053-10630022-35491520-6017

Av författaren/redakt...: Nordström, Josef ...; Klevan, Ingvild; Alderborn, Göran

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmaceutiska ve ...

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