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Moisturizers change...
Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids
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- Buraczewska, Izabela (författare)
- Uppsala universitet,Dermatologi och venereologi
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- Berne, Berit (författare)
- Uppsala universitet,Dermatologi och venereologi
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Lindberg, Magnus (författare)
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Lodén, Marie (författare)
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- Törmä, Hans (författare)
- Uppsala universitet,Dermatologi och venereologi
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(creator_code:org_t)
- 2009-05-23
- 2009
- Engelska.
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Ingår i: Archives of Dermatological Research. - : Springer Science and Business Media LLC. - 0340-3696 .- 1432-069X. ; 301:8, s. 587-594
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In a previous study, 7-week treatment of normal human skin with two test moisturizers, Complex cream and Hydrocarbon cream, was shown to affect mRNA expression of certain genes involved in keratinocyte differentiation. Moreover, the treatment altered transepidermal water loss (TEWL) in opposite directions. In the present study, the mRNA expression of genes important for formation of barrier lipids, i.e., cholesterol, free fatty acids and ceramides, was examined. Treatment with Hydrocarbon cream, which increased TEWL, also elevated the gene expression of GBA, SPTLC2, SMPD1, ALOX12B, ALOXE3, and HMGCS1. In addition, the expression of PPARG was decreased. On the other hand, Complex cream, which decreased TEWL, induced only the expression of PPARG, although not confirmed at the protein level. Furthermore, in the untreated skin, a correlation between the mRNA expression of PPARG and ACACB, and TEWL was found, suggesting that these genes are important for the skin barrier homeostasis. The observed changes further demonstrate that long-term treatment with certain moisturizers may induce dysfunctional skin barrier, and as a consequence several signaling pathways are altered.
Nyckelord
- Long-term treatment
- Moisturizers
- Skin barrier function
- Gene expression
- Arachidonate lipoxygenases
- PPAR
- MEDICINE
- MEDICIN
- Dermatology and Venerology
- Dermatologi och venereologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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