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No evidence of asso...
No evidence of association between genetic variants of the PDCD1 ligands and SLE
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- Abelson, Anna-Karin (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Johansson, Cecilia M. (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Kozyrev, Sergey V. (author)
- Uppsala universitet,Institutionen för genetik och patologi
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show more...
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- Kristjansdottir, Helga (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Gunnarsson, Iva (author)
- Karolinska Institutet
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- Svenungsson, Elisabet (author)
- Karolinska Institutet
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Lima, Guadalupe (author)
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Scherbarth, Hugo R (author)
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Gamron, Susana (author)
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Allievi, Alejandro (author)
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Palatnik, Sergio A (author)
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Alvarellos, Antonio (author)
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Paira, Sergio (author)
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Graf, Cesar (author)
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Guillerón, Carlos (author)
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Catoggio, Luis J (author)
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Prigione, Carlos (author)
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Battagliotti, Cesar G (author)
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Berbotto, Guillermo A (author)
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García, Mercedes A (author)
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Perandones, Carlos E (author)
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Truedsson, Lennart (author)
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Steinsson, Kristjan (author)
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- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Pons-Estel, Bernardo (author)
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- Alarcón-Riquelme, Marta E. (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Garcia, Ma (author)
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Grp, Argentinean Collaborative (author)
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(creator_code:org_t)
- 2006-11-30
- 2007
- English.
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In: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:1, s. 69-74
- Related links:
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https://www.nature.c...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z=2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N=149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N=90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- systemic lupus erythematosus
- genetic association
- linkage disequilibrium
- autoimmunity
- PD-L1
- PD-L2
- MEDICINE
- MEDICIN
- systemic lupus erythematosus
- genetic association
- linkage disequilibrium
- autoimmunity
- PD-L1
- PD-L2
Publication and Content Type
- ref (subject category)
- art (subject category)
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Abelson, Anna-Ka ...
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Johansson, Cecil ...
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Kozyrev, Sergey ...
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Kristjansdottir, ...
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Gunnarsson, Iva
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Svenungsson, Eli ...
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show more...
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Jönsen, Andreas
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Lima, Guadalupe
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Scherbarth, Hugo ...
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Gamron, Susana
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Allievi, Alejand ...
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Palatnik, Sergio ...
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Alvarellos, Anto ...
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Paira, Sergio
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Graf, Cesar
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Guillerón, Carlo ...
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Catoggio, Luis J
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Prigione, Carlos
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Battagliotti, Ce ...
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Berbotto, Guille ...
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García, Mercedes ...
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Perandones, Carl ...
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Truedsson, Lenna ...
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Steinsson, Krist ...
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Sturfelt, Gunnar
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Pons-Estel, Bern ...
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Alarcón-Riquelme ...
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Garcia, Ma
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Grp, Argentinean ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Genes and Immuni ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet