A mutation in hairless dogs implicates FOXI3 in ectodermal development

Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.

Karlsson, Elinor K (author)
Hytönen, Marjo K (author)
Perloski, Michele (author)
Dolf, Gaudenz (author)
Sainio, Kirsi (author)
Lohi, Hannes (author)
Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)kerli865 (author)
Leeb, Tosso (author)
Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

In:Science: American Association for the Advancement of Science (AAAS)321:5895, s. 1462-0036-80751095-9203

By the author/editor: Drögemüller, Cor ...; Karlsson, Elinor ...; Hytönen, Marjo K; Perloski, Michel ...; Dolf, Gaudenz; Sainio, Kirsi; show more...; Lohi, Hannes; Lindblad-Toh, Ke ...; Leeb, Tosso; show less...

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