Relative importance and conjoint effects of obesity and physical inactivity for the development of insulin resistance

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MARC

Ingelsson, ErikKarolinska Institutet,Uppsala universitet,Geriatrik (author)

Relative importance and conjoint effects of obesity and physical inactivity for the development of insulin resistance

Article/chapterEnglish2009

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2009
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LIBRIS-ID:oai:DiVA.org:uu-98656
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98656URI
https://doi.org/10.1097/HJR.0b013e328319bf8cDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:118461224URI
https://urn.kb.se/resolve?urn=urn:nbn:se:du-3495URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: Obesity and physical inactivity are related to the development of insulin resistance, but their relative importance and conjoint effects are unclear. METHODS: We related body mass index (BMI) and self-reported leisure-time physical activity (PA) at the age of 50 years to insulin sensitivity measured with euglycemic insulin clamp technique and the presence of metabolic syndrome (MetS) at a subsequent examination, 20 years later, in 862 men free from diabetes and MetS at baseline. RESULTS: In a multivariable model including BMI, PA, homeostasis model assessment insulin resistance index, erythrocyte sedimentation rate, and all components of MetS at baseline, both BMI (beta, -0.19 mg/kg bodyweight/min per 1 kg/m; P<0.0001) and PA (adjusted least square means, 5.1, 5.2, 5.4, and 6.2 mg/kg bodyweight/min in individuals with sedentary, moderate, regular, and athletic PA, respectively; P=0.0035) were significant predictors of insulin sensitivity at age 70. When categorizing individuals into four groups by BMI and PA at baseline, insulin sensitivity at the age of 70 years decreased significantly over the following categories: multivariable-adjusted least square means, 5.8 (low BMI/high PA); 5.6 (low BMI/low PA); 5.1 (high BMI/high PA); and 4.6 (high BMI/low PA) mg/kg bodyweight/min, respectively; P value of less than 0.0001. CONCLUSION: In our community-based sample of middle-aged men, BMI and PA were independent predictors of insulin resistance after 20 years of follow-up. Our results imply that obesity and physical inactivity may increase insulin resistance and metabolic risk by partly independent pathways, and emphasize the importance of strategies that address both obesity and physical inactivity to achieve increased public health.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
body mass index
insulin resistance
metabolic syndrome X
obesity
physical activity
MEDICINE
MEDICIN
Orthopaedics
Ortopedi

Added entries (persons, corporate bodies, meetings, titles ...)

Ärnlöv, JohanHögskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap(Swepub:du)jan (author)
Sundström, JohanUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)johasund (author)
Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
Michaëlsson, KarlUppsala universitet,Ortopedi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)karlmich (author)
Byberg, LiisaUppsala universitet,Ortopedi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)liisbybe (author)
Uppsala universitetGeriatrik (creator_code:org_t)

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In:European Journal of Cardiovascular Prevention & Rehabilitation16:1, s. 28-331741-82671741-8275

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By the author/editor: Ingelsson, Erik; Ärnlöv, Johan; Sundström, Johan; Risérus, Ulf; Michaëlsson, Kar ...; Byberg, Liisa

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Uppsala University; Karolinska Institutet; Högskolan Dalarna

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