Sökning: WFRF:(Boström Elisabeth A.) >
Association of sali...
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Silbereisen, AngelikaKarolinska Institutet
(författare)
Association of salivary TREM-1 and PGLYRP1 inflammatory markers with non-communicable diseases.
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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John Wiley & Sons,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:mau-61999
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-61999URI
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https://doi.org/10.1111/jcpe.13858DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153415083URI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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AIM: Triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are elevated in biofluids in the presence of various inflammatory conditions. This cross-sectional study aimed to evaluate the effect of age, sex, smoking and different oral and systemic non-communicable diseases on the levels of TREM-1 and PGLYRP1 in saliva.MATERIALS AND METHODS: In total, 445 individuals (mean age 48.7 ± 16.9 years, female:male 51%:49%) were included. All provided self-reported information on smoking and systemic diseases and whole stimulated saliva. Periodontal and cariological parameters were recorded. Salivary levels of TREM-1, PGLYRP1 and total protein were measured using commercially available assays.RESULTS: Salivary TREM-1 levels were significantly higher in stages III-IV periodontitis compared to other periodontal diagnoses (p < .05). Smoking, bleeding on probing (BOP), percentage of pockets ≥4 mm and the number of manifest caries were associated with TREM-1 (p < .05), while sex, BOP, number of manifest caries and muscle and joint diseases were associated with PGLYRP1 (p < .05).CONCLUSIONS: Salivary TREM-1 is associated with periodontitis and caries, while PGLYRP1 is associated with gingival inflammation and caries. Additionally, TREM-1 levels are modified by smoking, while PGLYRP1 is modified by sex and muscle and joint diseases. TREM-1 and PGLYRP1 in saliva could serve as potential biomarkers for detecting and monitoring non-communicable diseases.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lira-Junior, RonaldoKarolinska Institutet
(författare)
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Åkerman, SigvardMalmö universitet,Odontologiska fakulteten (OD)(Swepub:mau)odsiak
(författare)
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Klinge, BjörnKarolinska Institutet,Malmö universitet,Odontologiska fakulteten (OD),Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:mau)odbjkl
(författare)
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Boström, Elisabeth AKarolinska Institutet
(författare)
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Bostanci, NagihanKarolinska Institutet
(författare)
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Karolinska InstitutetOdontologiska fakulteten (OD)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Periodontology: John Wiley & Sons50:11, s. 1467-14750303-69791600-051X
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