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WFRF:(Boström Elisabeth A.)
 

Sökning: WFRF:(Boström Elisabeth A.) > Association of sali...

  • Silbereisen, AngelikaKarolinska Institutet (författare)

Association of salivary TREM-1 and PGLYRP1 inflammatory markers with non-communicable diseases.

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:mau-61999
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-61999URI
  • https://doi.org/10.1111/jcpe.13858DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153415083URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • AIM: Triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are elevated in biofluids in the presence of various inflammatory conditions. This cross-sectional study aimed to evaluate the effect of age, sex, smoking and different oral and systemic non-communicable diseases on the levels of TREM-1 and PGLYRP1 in saliva.MATERIALS AND METHODS: In total, 445 individuals (mean age 48.7 ± 16.9 years, female:male 51%:49%) were included. All provided self-reported information on smoking and systemic diseases and whole stimulated saliva. Periodontal and cariological parameters were recorded. Salivary levels of TREM-1, PGLYRP1 and total protein were measured using commercially available assays.RESULTS: Salivary TREM-1 levels were significantly higher in stages III-IV periodontitis compared to other periodontal diagnoses (p < .05). Smoking, bleeding on probing (BOP), percentage of pockets ≥4 mm and the number of manifest caries were associated with TREM-1 (p < .05), while sex, BOP, number of manifest caries and muscle and joint diseases were associated with PGLYRP1 (p < .05).CONCLUSIONS: Salivary TREM-1 is associated with periodontitis and caries, while PGLYRP1 is associated with gingival inflammation and caries. Additionally, TREM-1 levels are modified by smoking, while PGLYRP1 is modified by sex and muscle and joint diseases. TREM-1 and PGLYRP1 in saliva could serve as potential biomarkers for detecting and monitoring non-communicable diseases.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lira-Junior, RonaldoKarolinska Institutet (författare)
  • Åkerman, SigvardMalmö universitet,Odontologiska fakulteten (OD)(Swepub:mau)odsiak (författare)
  • Klinge, BjörnKarolinska Institutet,Malmö universitet,Odontologiska fakulteten (OD),Section of Periodontology and Dental Prevention, Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:mau)odbjkl (författare)
  • Boström, Elisabeth AKarolinska Institutet (författare)
  • Bostanci, NagihanKarolinska Institutet (författare)
  • Karolinska InstitutetOdontologiska fakulteten (OD) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Periodontology: John Wiley & Sons50:11, s. 1467-14750303-69791600-051X

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